Once Upon a Time in Hollywood is Quentin Tarantino's film about Los Angeles in 1969, with Leonardo DiCaprio, Brad Pitt, and Margot Robbie. Sweeney has a small part as Snake, one of the young followers of Charles Manson who live at the Spahn Ranch.

She is on screen for a few minutes, in the long sequence in which the stuntman played by Brad Pitt visits the ranch. The film came out in the same summer as the first season of Euphoria, and gave her a credit in a Tarantino film at the age of 21.

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Sydney Sweeney in Once Upon a Time in Hollywood

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